Blog

Nov 30, 2023

Excessive flexed position of the femoral component causes abnormal kinematics and joint contact/ ligament forces in total knee arthroplasty

Scientific Reports volume 13,

Scientific Reports volume 13, Article number: 6356 (2023) Cite this article

337 Accesses

Metrics details

Poor clinical outcomes are reported in excessive flexion of the femoral component in total knee arthroplasty (TKA), but their mechanisms have not yet been elucidated. This study aimed to investigate the biomechanical effect of flexion of the femoral component. Cruciate-substituting (CS) and posterior-stabilised (PS) TKA were reproduced in a computer simulation. The femoral component was then flexed from 0° to 10° with anterior reference, keeping the implant size and the extension gap. Knee kinematics, joint contact, and ligament forces were evaluated in deep-knee-bend activity. When the femoral component was flexed 10° in CS TKA, paradoxical anterior translation of the medial compartment was observed at mid-flexion. The PS implant was best stabilised with a 4° flexion model in mid-flexion range. The medial compartment contact force and the medial collateral ligament (MCL) force increased with the flexion of the implant. There were no remarkable changes in the patellofemoral contact force or quadriceps in either implant. In conclusions, excessive flexion of the femoral component yielded abnormal kinematics and contact/ligament forces. Avoiding excessive flexion and maintaining mild flexion of the femoral component would provide better kinematics and biomechanical effects in CS and PS TKA.

Total knee arthroplasty (TKA) has successfully improved the quality of life and daily activities of patients with end-stage knee arthritis1. Many factors can contribute to clinical outcomes, such as patient condition, implant design, and surgical technique1,2,3. Among surgical techniques, appropriate implant position is one of the key factors for the success of TKA4,5.

Although the optimal prosthetic alignment in the sagittal plane is unknown, a slightly flexed position of the femoral component has been recommended5,6. Extension of the femoral component can cause anterior femoral notching and may increase the patellofemoral contact pressure7,8. To avoid notching, the femoral component can be controlled to make the anterior flange nearly parallel to the anterior cortex of the femur9, and a slightly flexed position has been used in navigated TKA7,10. However, flexion of the femoral component increases the posterior condylar offset, which can affect knee kinematics and joint tightness11,12. A previous report showed that an increase of 2° in the sagittal flexion of the femoral component led to a decrease of 1 mm in the flexion gap11. Furthermore, both excessively extended and flexed positions are considered to overstress the polyethylene insert13,14.

In a computer simulation study, flexion of the femoral component with a posterior reference has been reported to improve kinematics and biomechanical effects in TKA8,15. However, in a previous study, excessive flexion was reported to yield inferior satisfaction and function16. In this study, a computer simulation study was employed to investigate the effect of flexion of the femoral component with an anterior reference on knee biomechanics. The hypothesis was that slight flexion of the femoral component would not affect kinematics and joint/ligament force; however, excessive flexion of the femoral component would show abnormal kinematics and/or abnormal joint/ligament force.

The present study was approved by Ethics Committee Graduate School and Faculty of Medicine Kymakioto University (registration number R0980) and was performed in accordance with the national Ethical Guidelines for Medical and Health Research Involving Human Subjects and ethical standards in the Declaration of Helsinki. The single participant, with whom the bone model was created, was provided informed consent for risk of this examination, including radiation exposure, and consented.

This study was performed using a musculoskeletal knee model in a computer simulation (LifeMOD/KneeSIM 2010; LifeModeler Inc., San Clemente, CA, USA). The simulation model consisted of a dynamic musculoskeletal program for knee modelling. The model included the tibiofemoral and patellofemoral contacts, lateral collateral ligament (LCL), medial collateral ligament (MCL), quadriceps muscle and tendon, patellar tendon, hamstring muscles, and elements of the knee capsule. All ligament bundles were modelled as nonlinear springs with material properties, as determined in a previous study17. The origins of the insertion points and stiffness were determined based on relevant anatomical studies18,19,20,21. The simulation program was previously validated to ensure appropriate estimates of kinematics, contact status, and contact force22,23. The computer simulation model with the attachments of ligaments, boundary conditions, and implants is shown in Fig. 1.

Computer-rendered images. (a) Overall picture of this study using Oxford-knee-rig. (b) Attachment of ligaments and boundary conditions with the Bi-Surface implant used in this study. (c) Simulation protocol and range of motion for deep knee bend. (d) Four computer simulation models with 0°, 4°, 7°, 10° flexion of the femoral component against distal femoral anatomical axis and implant down-size model with 10° component flexion in Bi-Surface implant.

Based on poor clinical outcomes due to excessive flexion position of the femoral component in Bi-Surface Knee (Kyocera, Kyoto, Japan)16, the Bi-Surface Knee System with cruciate-substituting (CS) tibial insert were used for the computer simulations in this study. The Bi-Surface Knee System is a unique prosthesis with promising long-term durability and consists of a ball-socket joint as a third condyle, which allows contact between the femoral component and the polyethylene dish even in deep flexion24. NexGen LPS-flex (Zimmer Biomet Inc., Warsow, IN, USA), which is a fixed-bearing posterior-stabilised (PS) implant with a multi-radius femoral component, was also evaluated as one of the most widely used prosthesis25.

The three-dimensional bone model was constructed from whole-leg computed tomography (CT) images in one healthy volunteer (age: 30 years old, sex: male, height: 170 cm, weight: 80 kg, hip-knee-ankle angle: 0.1°varus, medial proximal tibial angle: 86.9°, mechanical lateral distal femoral angle: 87.0°, anterior bowing angle of the femur: 4.2°, posterior tibial slope: 4.1°) , and TKA with two types of implants was simulated. To be used as the standard model, the coronal alignment of the femoral component was set perpendicular to the coronal mechanical axis of the femur with a sulcus cut to determine the thickness of the distal femoral cut. An anterior reference was used to determine the antero-posterior position of the femoral component. The sagittal alignment was parallel to the distal femoral anatomical axis, and the anterior condyle of the femur was cut flush to the anterior border of the femoral cortex, with axial rotation parallel to the surgical epicondylar axis. The tibial component was placed perpendicular to the mechanical axis of the tibia for coronal alignment, preserving a native posterior slope (4°)16, and the rotation was parallel to Akagi's line. Patella replacement was performed to maintain the original patellar thickness. An appropriately sized implant (femoral component size: Bi-Surface Knee; XLAG, LPS-flex; F) was placed in the computer simulation.

The computer simulation with the TKA prosthesis was used to simulate two cycles of squatting activity in a weight-bearing deep knee bend according to an Oxford-type knee rig (Fig. 1a,b). During the squatting activity, a constant vertical force was applied at the hip, corresponding to a body weight of 80 kg, which was converted to a ~ 4,000 N load on the knee. The knee model was flexed from full extension to 150° and then back to full extension within 4.5 s (Fig. 1c)26. During two cycles of the activity, the anteroposterior position of the facet centre of the medial and lateral compartment, the tibiofemoral intercomponent contact force of each condyle, patellofemoral contact force, collateral ligament forces, and quadricep muscle force were recorded. The values measured in the second squatting cycle were selected for the analyses because the first cycle was slightly unstable for fitting the bounding conditions of each intercomponent joint.

The experiments were performed by changing the sagittal alignment of the femoral component (Fig. 1d). First, the femoral component was rotated 4°, 7°, and 10° to flexion from the original position (0°) in the sagittal plane with an anterior reference. This rotation angle was selected based on the previous study in which the mean flexion angle of the femoral component was 4° with 3° of standard deviation, and patients with excessive flexion of the femoral component (≥ 8.5°) was inferior clinical outcomes16. The distal femoral cut was flexed from the original distal femoral anatomical axis, and the distal femoral cut was performed using a sulcus cut to preserve the extension gap. The most proximal point of the anterior flange was placed at the surface of the anterior femoral cortex to avoid notching or anterior overhang of the implant. The size of the implant was not changed, and the posterior overhang of the implant (6.7 mm and 6.3 mm increase in Bi-Surface Knee and LPS-flex, respectively, when flexing femoral component from 0° to 10°) was left. Secondly, the increased posterior overhang of the posterior condyle of the implant was reduced using an implant downsize (one size smaller) of a 10° flexion model.

In the Bi-Surface Knee with 10° of flexion of the femoral component, gradual posterior translation was observed in both condyles during the 15% to 25% cycle (40° to 70° of knee flexion), followed by paradoxical anterior translation of the medial compartment (Fig. 2a). When the femoral component was downsized while maintaining a 10° flexion of the femoral component, this abnormal movement was not observed. Posterior translation of the lateral compartment was observed before bicondylar rollback by the flexion of the femoral component (Fig. 2b). In the LPS-flex, the 4° flexion model showed relatively stable medial compartment in the mid-flexion range (20% to 40% cycle), while other flexion angles showed paradoxical anterior translations (Fig. 2c,d). With an increase in the flexion of the femoral component, the medial compartment moved anteriorly during bi-condylar roll-back in both implants, but the lateral compartment did not show any remarkable changes (Fig. 2a–d). By downsizing the implant, the facet centre of the medial and lateral compartment shifted anteriorly during the roll-back and roll-forward phases (Fig. 2a–d).

Antero-posterior translation of the facet centre of the Bi-Surface Knee (a: MC: medial compartment and b: LC lateral compartment) and the LPS-flex (c: MC, d: LC).

In terms of the contact force of each compartment, the contact force of the medial compartment peaked in the extension phase (75% to 80% cycle, 75° to 50° of knee flexion in the Bi-Surface Knee and 65% to 75% cycle, 120° to 75° of knee flexion in the LPS-flex) (Fig. 3a,d). In both implants, the peak contact force of the medial compartment increased with the flexion of the femoral component, but the contact force in the lateral compartment did not show any remarkable changes (Fig. 3a,b,d,e, Tables 1 and 2). By downsizing the femoral component, the medial contact force was considerably reduced (Fig. 3a,d, Tables 1 and 2). The patellofemoral contact force was not greatly changed by flexion of the femoral component (Fig. 3c,f, Tables 1 and 2).

Contact force in the Bi-Surface Knee (a–c) and LPS-flex (d–f). (a,d) medial compartment, (b,e) lateral compartment, (c,f) patellofemoral joint. MC medial compartment, LC lateral compartment, PF patellofemoral joint.

When ligament force was observed, the MCL force increased as the flexion of the femoral component increased, and each peak was observed in both the flexion and extension phases (Fig. 4a,d). These peak MCL forces were observed at approximately 25% to 30% and 75% to 80% cycles corresponding to the mid-flexion range (approximately 50° to 80° of knee flexion). Flexion of the femoral component from 7° to 10° of knee flexion showed a considerable increase in the MCL force in both implants, which was remarkably reduced by the downsizing of the femoral component (52% reduction in the Bi-Surface and 48% reduction in the LPS-flex from the original size) (Fig. 4a,d, Tables 3 and 4). The effect on LCL was smaller than that on MCL, and the quadriceps force was not dramatically changed by the flexion of the femoral component or implant size (Fig. 4b,c,e,f, Tables 3 and 4).

Ligament force in the Bi-Surface Knee (a–c) and LPS-flex (d–f). (a,d) medial collateral ligament, (b,e) lateral collateral ligament (c,f) quadriceps. MCL medial collateral ligament, LCL lateral collateral ligament.

This study demonstrated that excessive flexion of the femoral component increased the medial compartment contact force and MCL force in both CS and PS TKA. The Bi-Surface Knee showed mid-flexion instability which was represented by the paradoxical anterior translation when the implant was flexed at 10°. In the LPS-flex, a 4° flexion of the femoral component was most stabilised in mid-flexion, and other flexion angles showed paradoxical anterior translation. Taken together, slight flexion of the femoral component may be safe for knee biomechanics in these implants. Downsizing of the femoral component cancelled the increased contact and ligament forces, probably through decreased posterior overhang.

When each implant was compared, the Bi-surface Knee seemed more stable in mid-flexion range except 4°flexion model in which both implants showed good stabilization. Although the effect of flexion of the femoral component on contact and ligament force changes showed similar trends in both implants, the magnitude of peak contact force of Bi-Surface Knee was smaller than that of LPS-flex. In flexion range where LPS-flex showed peak contact force, a ball-socket joint in Bi-Surface knee had another contact area as a third condyle, which probably decrease the contact force of medial and lateral condyles. The differences in ligament forces in early to mid-flexion range was possibly due to the combined effect of stability, antero-posterior position, and rotation of the implant.

Previous studies have investigated the kinematic and biomechanical effects of flexion of the femoral component in TKA. A previous computer simulation study described that anteroposterior translation of the femoral component and quadriceps force decreased in both PS and cruciate-retaining TKA implants8,15 These studies evaluated a 10° range from − 3° of extension to 7° of flexion of the femoral component against the mechanical axis of the femur. In our study, the femoral component angle was defined against the distal femoral anatomical axis, which was 1.0° flexed to the mechanical axis of the femur in this case; the evaluation range was from 0° to 10° of flexion. Therefore, the investigated implant position was different from that used in previous studies. The other difference lies in the method of implant flexion. We flexed the femoral component with an anterior reference placed flush to the anterior cortex of the distal femur to avoid notch formation and anterior overhang of the femoral component. Thus, flexion of the femoral component resulted in an increase in the posterior overhang of the femoral component. In clinical reports, flexion of the femoral component and increased posterior condylar offset have been reported to be the result of posterior overhang of the femoral component16,27 However, in previous simulation articles, although the exact method of implant flexion was unclear, the femoral implant was flexed with a posterior reference, and anterior overhang of the anterior flange was observed8,15. In another biomechanical study using computer simulation, the effect of flexion and size of the implant was evaluated using cruciate-retaining TKA28 The evaluation range of flexion was 0° to 9° against the mechanical axis of the femur. In their study, the femoral component was also flexed with a posterior reference, and an increase of the posterior overhang was not created. The results showed that flexion of the femoral component increased the knee extensor moment arm in extension, reduced the quadriceps and patellofemoral contact forces, and provided stable kinematics. Downsizing of the femoral component shows mixed results, increasing patellofemoral contact force but decreasing medial patellofemoral ligament force and PCL force. The above-mentioned studies flexed the implant with a posterior reference, and flexion of the implant did not show a severe deteriorating effect on kinematics and biomechanics. In their model, anterior overhang of the anterior flange may exist, but posterior overhang was not observed. In contrast, in our study, the implant was flexed with anterior reference; therefore, increased posterior overhang caused a decrease in the flexion gap, leading to an increase in the joint/ligament force in the extensive flexion model.

The downsizing of the implant reduces the joint/ligament force without causing severe abnormal kinematics. When the posterior overhang was compared, the 4° flexion and 10° flexion downsize models had similar posterior overhangs. When the initial intramedullary guide was mistakenly inserted in the flexion position and anterior reference TKA was successfully performed by appropriate sizing of the posterior condyle, posterior overhang was avoided. This is the condition of the downsize model used in this study. However, posterior overhang could not be avoided when the implant was mistakenly flexed during implantation. In a previous study, 23% of undesired flexion of the femoral component was reported during the final implantation29. This error causes posterior overhang, which could result in excessive flexion in this study.

Clinically, the effects of flexion of the femoral component have been reported in various aspects. In terms of the longevity of the implant, flexion of the femoral component was one of the risk factors for revision TKA because anterior overhang of the anterior flange of the flexed implant might irritate the quadriceps tendon and cause patellar crepitus30. Another study reported that femoral implants with more than 3° of flexion have higher failure rates compared to neutral (0° to 3° of flexion) and extended femoral components31. As for the clinical outcomes, one study showed that patients with excessive flexion of the femoral component (> 8.5°) had inferior outcomes, although there was a wide safety range, which yielded good satisfaction and function16. Another study using a machine learning model prediction showed that the likelihood of being ‘satisfied or very satisfied’ and a knee ‘always feeling normal’ increased with a change in the tibial slope within 2° from the native slope and femoral component flexion of 0° to 7°4. It has been reported that although there is no consensus in the acceptable range of the sagittal alignment of the femoral component, excessive flexion should be avoided5,6,7,8. Currently, there is no definitive angle to illustrate ‘excessive’ flexion, but when observing the biomechanics of two types of implants, 10° of flexion to the distal femoral anatomical axis seemed to be an ‘excessive’ flexion, as it resulted in abnormal kinematics and excessive joint contact/ligament forces in both implants.

This study had several limitations. First, the simulation consisted of a virtual and variable model with a generally healthy knee joint consisting of interpolated material properties from cadaver studies. The kinematics and obtained forces have been validated for physiologically relevant motions of TKA, but the values obtained might not be entirely the same as in living patients with end-stage arthritis. Second, no statistical analysis was performed because a standard bone model was used in this study. Single healthy bone model which was validated with the real knee motion in fluoroscopic analysis was used in this study. Due to the ethical reason according to radiographic exposure, multiple bone models are currently unavailable. Changing the experimental conditions in a bone model, which was hard to be performed in the real world, is the strength of the computer simulation study, and numbers of studies have reported using single validated bone model8,25,26,28,32,33,34. However, there are anatomic variations depending on sex, race and individual even in healthy volunteer35. Progression of osteoarthritis possibly has additional anatomical change on femoral bowing, tibia vara, or tibial slope36,37. Preoperative and postoperative lower-leg alignment may affect the biomechanics after TKA38. However, only a neutral alignment bone model was simulated using a mechanical alignment TKA. Thus, further research on multiple bone models including an osteoarthritis knee would be ideal to obtain more representative information mimicking real-life clinical situations. Third, only two fixed-bearing implants, one CS and one PS implant were analysed in this study. It is unclear whether similar results would be obtained in cruciate-retaining or mobile-bearing TKA. Moreover, even within CS and PS TKA, optimal flexion of the femoral component may differ among prosthesis due to the difference in surface geometry. However, at least in the two implants evaluated in this study, excessive flexion of the femoral component was warned, as with poor outcomes in clinical studies4,16. Further studies with various types of implants would be ideal to generalise the effect of excessive flexion of the femoral component.

In conclusions, mild flexion of the 4° femoral component showed stabilised mid-flexion during deep knee bend activity, and the medial joint/ligament force increased as the flexion of the femoral component increased. As suggested by clinical studies, mild flexion of the femoral component is good for the target sagittal alignment of the femoral component, and excessive flexion should be avoided in light of knee biomechanics.

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

Matsuda, S., Kawahara, S., Okazaki, K., Tashiro, Y. & Iwamoto, Y. Postoperative alignment and ROM affect patient satisfaction after TKA. Clin. Orthop. Relat. Res. 471, 127–133 (2013).

Article PubMed Google Scholar

Grave, P. W. et al. Higher satisfaction after total knee arthroplasty using restricted inverse kinematic alignment compared to adjusted mechanical alignment. Knee Surg. Sports Traumatol. Arthrosc. 30, 488–499 (2022).

Article Google Scholar

Hamilton, D. F. et al. Implant design influences patient outcome after total knee arthroplasty: A prospective double-blind randomised controlled trial. Bone Joint J. 97, 64–70 (2015).

Article PubMed Google Scholar

Farooq, H., Deckard, E. R., Arnold, N. & Meneghini, R. M. Machine learning algorithms identify optimal sagittal component position in total knee arthroplasty. J. Arthroplasty 36, S242–S249 (2021).

Article PubMed Google Scholar

Gromov, K., Korchi, M., Thomsen, M. G., Husted, H. & Troelsen, A. What is the optimal alignment of the tibial and femoral components in knee arthroplasty?. Acta Orthop. 85, 480–487 (2014).

Article PubMed PubMed Central Google Scholar

Matziolis, G., Krocker, D., Weiss, U., Tohtz, S. & Perka, C. A prospective, randomized study of computer-assisted and conventional total knee arthroplasty. Three-dimensional evaluation of implant alignment and rotation. J. Bone Joint Surg. Am. 89, 236–243 (2007).

Article PubMed Google Scholar

Minoda, Y., Kobayashi, A., Iwaki, H., Ohashi, H. & Takaoka, K. TKA sagittal alignment with navigation systems and conventional techniques vary only a few degrees. Clin. Orthop. Relat. Res. 467, 1000–1006 (2009).

Article PubMed Google Scholar

Kang, K. T., Koh, Y. G., Son, J., Kwon, O. R. & Park, K. K. Flexed femoral component improves kinematics and biomechanical effect in posterior stabilized total knee arthroplasty. Knee Surg. Sports Traumatol. Arthrosc. 27, 1174–1181 (2019).

Article PubMed Google Scholar

Lu, Z. H. et al. Computed tomographic measurement of gender differences in bowing of the sagittal femoral shaft in persons older than 50 years. J. Arthroplasty 27, 1216–1220 (2012).

Article PubMed Google Scholar

Chung, B. J., Kang, Y. G., Chang, C. B., Kim, S. J. & Kim, T. K. Differences between sagittal femoral mechanical and distal reference axes should be considered in navigated TKA. Clin. Orthop. Relat. Res. 467, 2403–2413 (2009).

Article PubMed PubMed Central Google Scholar

Tsukeoka, T. & Lee, T. H. Sagittal flexion of the femoral component affects flexion gap and sizing in total knee arthroplasty. J. Arthroplasty 27, 1094–1099 (2012).

Article PubMed Google Scholar

Roßkopf, J., Singh, P. K., Wolf, P., Strauch, M. & Graichen, H. Influence of intentional femoral component flexion in navigated TKA on gap balance and sagittal anatomy. Knee Surg. Sports Traumatol. Arthrosc. 22, 687–693 (2013).

Article PubMed Google Scholar

Li, G. et al. Anterior tibial post impingement in a posterior stabilized total knee arthroplasty. J. Orthop. Res. 23, 536–541 (2005).

Article PubMed Google Scholar

Collier, M. B., Engh, C. A., McAuley, J. P., Ginn, S. D. & Engh, G. A. Osteolysis after total knee arthroplasty: Influence of tibial baseplate surface finish and sterilization of polyethylene insert. Findings at five to ten years postoperatively. J. Bone Joint Surg. Am. 87, 2702–2708 (2005).

PubMed Google Scholar

Koh, Y. G., Hong, H. T., Lee, H. Y., Kim, H. J. & Kang, K. T. Influence of variation in sagittal placement of the femoral component after cruciate-retaining total knee arthroplasty. J. Knee Surg. 34, 444–451 (2021).

Article PubMed Google Scholar

Nishitani, K. et al. Excessive flexed position of the femoral component was associated with poor new Knee Society Score after total knee arthroplasty with the Bi-Surface knee prosthesis. Bone Joint J. 102, 36–42 (2020).

Article PubMed Google Scholar

Blankevoort, L., Kuiper, J. H., Huiskes, R. & Grootenboer, H. J. Articular contact in a three-dimensional model of the knee. J. Biomech. 24, 1019–1031 (1991).

Article CAS PubMed Google Scholar

Park, S. E. et al. The change in length of the medial and lateral collateral ligaments during in vivo knee flexion. Knee 12, 377–382 (2005).

Article PubMed Google Scholar

LaPrade, R. F. et al. The anatomy of the medial part of the knee. J. Bone Joint Surg. Am. 89, 2000–2010 (2007).

Article PubMed Google Scholar

Wijdicks, C. A. et al. Structural properties of the primary medial knee ligaments. Am. J. Sports Med. 38, 1638–1646 (2010).

Article PubMed Google Scholar

Belvedere, C. et al. Geometrical changes of knee ligaments and patellar tendon during passive flexion. J. Biomech. 45, 1886–1892 (2012).

Article CAS PubMed Google Scholar

Okamoto, S. et al. Effect of tibial posterior slope on knee kinematics, quadriceps force, and patellofemoral contact force after posterior-stabilized total knee arthroplasty. J. Arthroplasty 30, 1439–1443 (2015).

Article PubMed Google Scholar

Tanaka, Y. et al. How exactly can computer simulation predict the kinematics and contact status after TKA? Examination in individualized models. Clin. Biomech. 39, 65–70 (2016).

Article Google Scholar

Nakamura, S. et al. Long-term durability of ceramic tri-condylar knee implants: A minimum 15-year follow-up. J. Arthroplasty 32, 1874–1879 (2017).

Article PubMed Google Scholar

Watanabe, M. et al. Impact of intraoperative adjustment method for increased flexion gap on knee kinematics after posterior cruciate ligament-sacrificing total knee arthroplasty. Clin. Biomech. 63, 85–94 (2019).

Article Google Scholar

Sekiguchi, K. et al. Effect of tibial component alignment on knee kinematics and ligament tension in medial unicompartmental knee arthroplasty. Bone Joint Res. 8, 126–135 (2019).

Article CAS PubMed PubMed Central Google Scholar

Ng, N., Patton, J. T., Burnett, R. & Clement, N. D. Sagittal alignment of the cemented femoral component in revision total knee arthroplasty influences the anterior and posterior condylar offset: Stem length does not affect these variables. Knee 27, 477–484 (2020).

Article CAS PubMed Google Scholar

Marra, M. A. Flexing and downsizing the femoral component is not detrimental to patellofemoral biomechanics in posterior-referencing cruciate-retaining total knee arthroplasty. Knee Surg. Sports Traumatol. Arthrosc. 26, 3377–3385 (2018).

Article PubMed PubMed Central Google Scholar

Kuriyama, S. et al. Bone-femoral component interface gap after sagittal mechanical axis alignment is filled with new bone after cementless total knee arthroplasty. Knee Surg. Sports Traumatol. Arthrosc. 26, 1478–1484 (2018).

Article PubMed Google Scholar

Dennis, D. A. et al. The John Insall Award: control-matched evaluation of painful patellar Crepitus after total knee arthroplasty. Clin. Orthop. Relat. Res. 469, 10–17 (2011).

Article PubMed Google Scholar

Kim, Y. H., Park, J. W., Kim, J. S. & Park, S. D. The relationship between the survival of total knee arthroplasty and postoperative coronal, sagittal and rotational alignment of knee prosthesis. Int. Orthop. 38, 379–385 (2014).

Article PubMed Google Scholar

Mizu-uchi, H. et al. Tibial sagittal and rotational alignment reduce patellofemoral stresses in posterior stabilized total knee arthroplasty. Sci. Rep. 12, 12319 (2022).

Article ADS CAS PubMed PubMed Central Google Scholar

Nishitani, K. et al. Valgus position of the femoral component causes abnormal kinematics in the presence of medial looseness in total knee arthroplasty: A computer simulation model of TKA for valgus knee osteoarthritis. Knee Surg. Sports Traumatol. Arthrosc. 27, 2051–2060 (2019).

Article PubMed Google Scholar

Kuriyama, S., Ishikawa, M., Furu, M., Ito, H. & Matsuda, S. Malrotated tibial component increases medial collateral ligament tension in total knee arthroplasty. J. Orthop. Res. 32, 1658–1666 (2014).

Article PubMed Google Scholar

MacDessi, S. J., Griffiths-Jones, W., Harris, I. A., Bellemans, J. & Chen, D. B. Coronal plane alignment of the knee (CPAK) classification. Bone Joint J. 103, 329–337 (2021).

Article PubMed Google Scholar

Higano, Y. et al. The varus alignment and morphologic alterations of proximal tibia affect the onset of medial knee osteoarthritis in rural Japanese women: Case control study from the longitudinal evaluation of Matsudai Knee Osteoarthritis Survey. J. Orthop. Sci. 21, 166–171 (2016).

Article PubMed Google Scholar

Umatani, N. et al. Femoral bowing affects varus femoral alignment but not patient satisfaction in mechanically aligned total knee arthroplasty. Eur. J. Orthop. Surg. Traumatol. 33, 89–96 (2023).

Article PubMed Google Scholar

Song, Y. et al. Biomechanical comparison of kinematic and mechanical knee alignment techniques in a computer simulation medial pivot total knee arthroplasty model. J. Knee Surg. https://doi.org/10.1055/s-0041-1740392 (2021).

Article PubMed Google Scholar

Download references

Authors thanks Drs. Yoshihisa Tanaka and Mutsumi Watanabe for their technical supports. The authors also thank Editage for English editing.

Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-Cho, Sakyo-Ku, Kyoto, 606-8507, Japan

Kohei Nishitani, Shinichi Kuriyama, Shinichiro Nakamura, Young Dong Song, Yugo Morita, Hiromu Ito & Shuichi Matsuda

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

K.N. contributed to study design, data analysis, interpretation, and wrote the manuscript. S.K., S.N. and H.I. contributed to data analysis, interpretation and revising the manuscript. Y.S. and Y.M. contributed to data acquisition. S.M. contributed to conception and interpretation, revising the manuscript, and supervised the study. All the authors read and approved the manuscript.

Correspondence to Kohei Nishitani.

KN, and SN received research grant from Kyocera. SM received research grant, consulting fee, and honorarium for a lecture from Kyocera and honorarium for a lecture Zimmer-Biomet. Rest all authors declare no competing interests.

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and Permissions

Nishitani, K., Kuriyama, S., Nakamura, S. et al. Excessive flexed position of the femoral component causes abnormal kinematics and joint contact/ ligament forces in total knee arthroplasty. Sci Rep 13, 6356 (2023). https://doi.org/10.1038/s41598-023-33183-2

Download citation

Received: 14 January 2023

Accepted: 08 April 2023

Published: 19 April 2023

DOI: https://doi.org/10.1038/s41598-023-33183-2

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.